RESUMO
We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.
Assuntos
Aspergillus/isolamento & purificação , Betacoronavirus , Infecções por Coronavirus/patologia , Aspergilose Pulmonar Invasiva/patologia , Pneumonia Viral/patologia , Idoso , Aspergillus/genética , Autopsia , COVID-19 , Infecções por Coronavirus/complicações , Evolução Fatal , Humanos , Aspergilose Pulmonar Invasiva/complicações , Pulmão/microbiologia , Masculino , Pandemias , Pneumonia Viral/complicações , SARS-CoV-2RESUMO
Abstract We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.
